PixCell’s Viscoelastic Focusing Technology Shifts the Paradigm in Hematology Point of Care Accessibility

PixCell’s Viscoelastic Focusing Technology Shifts the Paradigm in Hematology Point of Care Accessibility

July 24, 2019 | PixCell Medical Technologies Ltd. Booth #814

Pixcell’s HemoScreen™ is a portable cartridge driven platform. It is fast, simple to use, and a cost-effective means of providing crucial diagnostic information, near patient, where it is needed most.

In the Point of Care community, the quest for CLIA waiver status has driven hematology Manufacturers to look for simpler, more failsafe, error free solutions for turning out a Complete Blood Count (CBC). Most of the current solutions require multiple methodologies (Channels) to measure various cellular components in a blood sample. The deficiencies of most methods are well documented from operational complexities to erroneous results subject to interfering substances. 

Pixcell’s HemoScreen™proprietary Viscoelastic Focusing Technology is based on three principal innovations:

  1. Microfluidics and Visco Elastic Focusing
  2. Lab on a self–calibrating cartridge
  3. Machine vision and Artificial Intelligence

The combination of these approaches is the key for facilitating rapid, lab-accurate results in a miniature, easy-to-use instrument.

The HemoScreen technology is covered by over 22 issued and 14 pending patents in US, EU, Japan and China.

Visco Elastic Focusing (VEF) is a new physical phenomenon, discovered at the Technion in Israel. It causes cells to perfectly align into a single cell layer while flowing facilitating their optical analysis. Focusing of the cells is an inherent requirement in all cell counters, that is achieved through hydrodynamic focusing which is cumbersome, sensitive to vibrations, clogging and requires large volumes of reagents. In contrast, VEF is extremely robust. It uses minute reagent volume and requires no complex geometries thus becoming the key in our design of a simple, inexpensive disposable. 

The analysis is based on machine vision which is a much more powerful and modern approach for cell classification. In contrast to the existing laser scattering or electric impedance methods, hundreds of features are extracted from each cell providing significantly better clarity and differentiation capabilities. This facilitates the differentiation between sub-types of cells and enumeration of abnormal cells which can only be flagged by the current analyzers. Furthermore, vision helps detect a multitude of problems and instrument malfunction thus guaranteeing robustness and accuracy of results.

PixCell Medical Technologies is a privately held Israeli company developing cell-based point of care (POC) diagnostics devices. PixCell’s first product, HemoScreen™, is a point of care complete blood count (CBC) system. It is CE marked, FDA cleared, and is currently being marketed in Europe.

Please visit us at Booth 814

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