Oxytocin, bone mass, and body fat

Experiments in which the receptor for the peptide hormone oxytocin was knocked out selectively in bone-forming and bone-resorbing cells of mice revealed that the hormone not only helps promote bone synthesis but also curbs bone loss during pregnancy and lactation–conditions in which fetal calcium demand is relatively high; despite suppressing the transformation of white fat into energy-burning beige fat in adipocytes, oxytocin administration reduced total body fat in mice, likely through the hormone’s action on oxytocin-responsive neurons, suggesting that oxytocin and its receptor might represent potential drug targets for osteoporosis and obesity, according to a study.

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Article #19-13611: “Oxytocin regulates body composition,” by Li Sun

et al

.

MEDIA CONTACT: Maria New, Icahn School of Medicine at Mount Sinai, New York, NY; e-mail:

[email protected]

This part of information is sourced from https://www.eurekalert.org/pub_releases/2019-12/potn-obm121119.php

Maria New

[email protected]

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