The new center will be funded under a five-year, $10.1 million grant from the National Institute of Allergy and Infectious Diseases (NIAID).
Already underway, the CRC, officially known as the “Cooperative Research Center for NanoScaffold-Based Chlamydia trachomatis Vaccines,” began operations on Oct. 1, 2019. It is led by co-directors, Matt Coleman, an LLNL biomedical scientist, and Professor Luis M. de la Maza, a pathologist at UCI’s School of Medicine and a worldwide leading expert in chlamydia vaccinology.
“By establishing a CRC for the formulation of a chlamydia vaccine, the NIH has created a wonderful opportunity for a collaborative effort involving three very prestigious institutions,” said de la Maza. “Leveraging the expertise of these three partners significantly increases our chances of successfully developing a vaccine that can be given to young individuals preventing them from contracting chlamydia and protecting them from the negative consequences of an infection.”
de la Maza’s lab has been working on a chlamydia vaccine for almost four decades. As a part of the CRC, their work will focus primarily on using the chlamydia outer membrane protein (MOMP) as the vaccine antigen. Other researchers, including UCI’s Ellena M. Peterson and Sukumar Pal, have also made significant contributions to this project.
Coleman, at LLNL, has developed methods to correctly fold membrane proteins in vitro. His team of scientists will build on a nanotechnology – called nanolipoprotein particles (NLPs) – for delivering the C. trachomatis vaccines.
At UC Davis, R. Holland Cheng’s lab will be using cryo-electron microscopy to characterize the structure of the native C. trachomatis MOMP. This structural characterization will help to inform the formulation of the MOMP in NLPs, effectively tying together the efforts of the three collaborative institutions.
C. trachomatis is the most common bacterial sexually transmitted infection in the country. Attempts to control this pathogen, with screening programs and antibiotic therapy, have so far failed. The number of cases of C. trachomatis infections reported to the Centers for Disease Control and Prevention (CDC) continuous to increase. In 2017, more than 1.7 million cases were reported. The long-term sequelae of a C. trachomatis infections in females include pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy and infertility. Babies born from infected mothers can develop conjunctivitis and pneumonia.
About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, as well as 200 doctoral and master’s students. More than 600 residents and fellows are trained at UC Irvine Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and master’s degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/master’s in public health, or an MD/master’s degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.
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