More studies needed on mental health treatments during and after pregnancy

Untreated mental health disorders can be a serious problem for women and their children during pregnancy and after giving birth, during the postpartum period. A recent analysis funded by the Agency for Healthcare Research and Quality (AHRQ) and published in


Psychiatric Research & Clinical Practice


notes that few studies have examined the benefits of medications for mental health disorders in pregnant and postpartum women. And while many studies have reported on potential harms, the large majority could not separate the effect of medications from the effect of the underlying disorder. As a result, it is not clear that these medications caused harms to pregnant or postpartum women.

A total of 164 studies were included in the analysis. Study results indicate that brexanolone and sertraline likely lessen depressive symptoms, and mood stabilizers may reduce recurrence of bipolar disorder.

“It’s vital for patients and providers to make informed decisions during pregnancy and postpartum, and our study shows a need for more and higher quality research in regards to mental health treatments,” said Meera Viswanathan PhD, of the AHRQ Evidence-based Practice Center at RTI International – University of North Carolina.

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