Kidney Resident Macrophages Share Properties across Species, May Lead to Targeted Treatment for Kidney Diseases

Article title: Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes

Authors: Kurt A. Zimmerman, Zhengqin Yang, Jeremie M. Lever, Zhang Li, Mandy J. Croyle, Anupam Agarwal, Bradley K. Yoder, James F. George

From the authors: “Our data raise the exciting possibility that there is significant redundancy in [kidney resident macrophage (KRM)] functional properties across species and suggest that targeting these cells may be an effective therapeutic strategy in diseases that are influenced by KRMs.”

This study is highlighted as one of September’s “best of the best” as part of the American Physiological Society’s APSselect program.