Increased Expression of PAK1 Enzyme Plays Role in Breast Cancer

Article title: Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase (PAK1) positive breast cancer

Authors: Emily L. Duderstadt, Sarah A. McQuaide, Mary Ann Sanders, David J. Samuelson

From the authors: “Our finding of elevated [p21 activated kinase 1 (PAK1)] expression in chemical carcinogen-induced non-diseased rat mammary glands further suggests that PAK1 has a role during early tumorigenesis of female breast cancer, potentially prior to the development of premalignant lesions.” 

This study is highlighted as one of February’s “best of the best” as part of the American Physiological Society’s APSselect program.