Hydrogen Sulfide Increases Expression of Ion Channels in the Brain

New research published ahead of print in the journal Function details the impact of hydrogen sulfide on increased expression of acid-sensing ion channels (ASICs) in the brain.

Hydrogen sulfide has been identified recently as a new gasotransmitter—gaseous molecules involved in a variety of physiological and cellular functions. The compound affects cell activity by interacting with proteins, including ASICs. In a new study, researchers explored the role of hydrogen sulfide in ASICs located in brain nerve cells (neurons).

“We show here that [hydrogen sulfide] donors increase currents of recombinantly expressed ASICs and of endogenous ASICs in cultured brain neurons. The current increases over time and stays increased for many hours,” the researchers wrote. “Our data suggest that this regulation, which is likely of importance in several physiological and pathological conditions, is mediated by the MAPK-Erk1/2 signaling pathway.”

Read the full article, “Hydrogen sulfide upregulates acid-sensing ion channels via the MAPK-Erk1/2 signaling pathway.” Contact the APS Communications Office to schedule an interview with the research team.