Genetics of glucocorticoid resistance in asthma

Genetic analysis of 502 people with severe asthma revealed a variant in the HSD3B1 gene, known to regulate androgen production, that is correlated with resistance to asthma treatment with glucocorticoids, suggesting a potentially personalized approach to the treatment of severe asthma, according to a study.

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Article #19-18819: “HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma,” by Joe Zein et al.

MEDIA CONTACT: Nima Sharifi, Cleveland Clinic Lerner College of Medicine, Cleveland, OH; tel: 216-445-9750; e-mail: <

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