The Latest from the Lab
Bone morphogenetic proteins are growth factors originally discovered as regulators in bone formation. My laboratory discovered that the bone morphogenetic protein (BMP) signaling pathway is unusually expressed in cancer and has a growth-promoting role. We discovered that a specific BMP receptor, BMP2, which is a protein expressed in embryos, has unique properties in cancer. When this protein is blocked, the growth of cancer cells decreases. Together with a group of collaborators, we are currently developing small molecules to target this specific BMP receptor. Thus far, we have developed potent inhibitors of this BMP receptor that leads to the suppression of several important genes known to promote the growth of cancer cells.
Beyond Lung Cancer
Recent studies suggest a role of deviant BMP signaling in promoting other age-related diseases including Alzheimer’s disease. We are also working to develop BMP inhibitors that can enter into the brain. Studies in mice suggest that blocking BMP in the brain enhances the development of new neurons, enhancing cognition. We have developed a new generation of BMP inhibitors that enter the brain and will be studied in a rapidly aging mouse model of Alzheimer’s disease.
Hopes for the Future
The team of scientists consists of biologists, medicinal chemists, synthetic chemists, computational biologists, neuroscientists, neuropathologists and X-ray crystallographers. This team of experts is uniquely qualified to bring this research into the clinic in the near future. Our goal is to develop a BMP inhibitor as a drug and examine its potential as therapy for lung and other cancers.
This work is supported in part by funding from the National Cancer Institute (R01CA225830 RO1CA225830-03S2 and R01CA225830-02S1) and a HealthAdvance grant from the Office of Rutgers Research Commercialization and National Institutes of Health REACH Program.
To learn more about the Lung Cancer/Thoracic Oncology Program at Rutgers Cancer Institute of New Jersey, visit: https://www.cinj.org/patient-care/adult/lung.