EPFL and researchers from Mass. Eye and Ear are developing next-generation hearing implants
Working with researchers from Massachusetts Eye and Ear and Harvard Medical School, a team of EPFL researchers has developed a conformable electrode implant that will allow people with a dysfunctional inner ear to hear again. This new technology would improve existing auditory brainstem implants, which have a number of shortcomings.
For these patients to recover their sense of hearing, electrical signals must be sent directly to the auditory brainstem. The neuroprosthetic used for this purpose is called an auditory brainstem implant, or ABI. Yet the outcomes of ABIs are modest with most patients recovering only sound awareness. What’s more, clinical ABIs are stiff and cannot conform precisely to the curvature of the auditory brainstem.
To address this problem, Stéphanie Lacour’s team at EPFL’s Laboratory for Soft BioElectronic Interface (LSBI) worked with researchers from Mass. Eye and Ear and Harvard Medical School to develop a soft electronic interface. The highly elastic implant conforms precisely to the curved surface of the auditory brainstem and can therefore send highly targeted electrical signals. It has been tested successfully on mice – the implant has a surface area only 0.25 mm2 – and has now been produced at a size suitable for human use and in a form that is compatible with current surgical techniques. It will undergo further study in preparation for human trials. The researchers’ study was just published in Science Translational Medicine. Dr. Lacour and Dr. Daniel Lee are co-senior authors on this paper.
Inspired by Japanese cutouts
The new implant consists of a conformable array of platinum electrodes encased in silicone. “We focused on platinum because it’s already used widely in clinical settings,” says Nicolas Vachicouras, a post-doc at EPFL’s School of Engineering and the article’s lead author.
Unfortunately, platinum is a rigid metal that cannot be distorted without being damaged. The researchers overcame this hurdle by applying the traditional Japanese paper-cutting technique called kirigami, etching a Y-shaped pattern into metalized plastic segments. Then they machined the metal at the micron scale (one micron = one thousandth of a millimeter), using techniques commonly found in the microfabrication of integrated circuits. The result is a very compliant and highly conductive electrode implant.
The EPFL researchers are already eyeing other applications. “The properties of our device would be of value for all sorts of implantable neuroprosthetics,” says Stéphanie Lacour, “such as those used to stimulate or record neural activity in the spine, brain or even peripheral nerves.”
The EPFL researchers worked closely with Dr. Lee’s team at Mass. Eye and Ear. Dr. Lee said, “This collaborative study between researchers in Boston and Geneva represents an important step towards improving the performance of the auditory brainstem implant (ABI), a specialized device that is used for patients who are deaf and are not cochlear implant (CI) candidates. Overall, ABI users have modest outcomes compared to CI users. We believe that the translation of our novel “soft” auditory brainstem implant technology that addresses the biomechanical mismatch between existing stiff implants and the curved surface of the brain will improve performance and reduce side effects.”
Dr. Lee runs a clinical and research program for ABI implants, with a focus on answering fundamental questions about how the ABI provides hearing using animal models and to examine novel methods to correlate position of the array with ABI outcomes in the clinic.
The project between the EPFL and Harvard Medical School has been a multi-year collaboration most recently supported by the Bertarelli Foundation.
About Massachusetts Eye and Ear
Massachusetts Eye and Ear, founded in 1824, is an international center for treatment and research and a teaching hospital of Harvard Medical School. A member of Partners HealthCare, Mass. Eye and Ear specializes in ophthalmology (eye care) and otolaryngology–head and neck surgery (ear, nose and throat care). Mass. Eye and Ear clinicians provide care ranging from the routine to the very complex. Also home to the world’s largest community of hearing and vision researchers, Mass. Eye and Ear scientists are driven by a mission to discover the basic biology underlying conditions affecting the eyes, ears, nose, throat, head and neck and to develop new treatments and cures. In the 2019–2020 “Best Hospitals Survey,” U.S. News & World Report ranked Mass. Eye and Ear #4 in the nation for eye care and #2 for ear, nose and throat care. For more information about life-changing care and research at Mass. Eye and Ear, visit our blog, Focus, and follow us on Instagram, Twitter and Facebook.
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