Depression risk higher after stroke vs. heart attack and female vs. male stroke survivors

DALLAS, March 11, 2021 — Stroke patients were nearly 50% more likely than heart attack patients to develop depression, and female stroke patients had a higher risk of depression than their male counterparts, according to two preliminary studies by the same research group to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health.

In what researchers described as one of the largest study of post-stroke depression to-date, they conducted two investigations using the same U.S. Medicare dataset of patients ages 65 or older hospitalized for ischemic stroke or heart attack from July 2016 to December 31, 2017. Among more than 11 million Medicare beneficiaries who were admitted during the two-year study period, there were 174,901 with admission for ischemic stroke and 193,418 with admission for heart attack. Patients were followed for 1.5 years, and patients with prior history of depression in the six months preceding their stroke or heart attack were excluded.

“Depression following stroke is almost three times as common as it is in the general population and may affect up to a third of stroke patients. Patients with post-stroke depression also experience poorer quality of life and outcomes,” said lead author Laura K. Stein, M.D., M.P.H., assistant professor of neurology at the Icahn School of Medicine at Mount Sinai and an attending neurologist at Mount Sinai and Mount Sinai Queens Stroke Centers in New York City.

In the first study (Presentation 22), researchers found:

• The risk of depression was about 50% more likely among patients who had a stroke (174,901) compared to patients who had a heart attack (193,418).
• History of anxiety was found in 10.3% of ischemic stroke patients and 11.8% of heart attack patients. Ischemic stroke patients with a history of anxiety were 1.7 times more likely to develop depression than patients without anxiety.
• History of anxiety was the strongest predictor of post-stroke depression, while being discharged home resulted in less depression.
• White patients were 1.33 times more likely to be diagnosed with post-stroke depression.
• Patients 75 and older were 0.79 times less likely to be diagnosed with post-stroke depression.

“We did not expect that the cumulative risk of depression would remain so persistently elevated. This finding supports that post-stroke depression is not simply a transient consequence of difficulties adjusting to life after stroke,” Stein said.

In another analysis by the same researchers (Presentation 21), female stroke patients (90,474) had a 20% higher risk of developing depression than male stroke patients (84,427).

Drawing from the same Medicare pool of patients, a comprehensive inpatient, outpatient and subacute nursing follow-up helped to detect new-onset depression more accurately compared to studies that don’t have follow up from multiple settings where depression may be tracked. Researchers calculated the increasing risk for depression in females vs. males over 1.5 years of follow-up.

“Our current findings highlight the need for active screening and treatment for depression in the time period immediately and well after the stroke and the importance of screening all stroke patients for post-stroke depression, including women and those with a history of mental illness,” Stein said.

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Co-authors of both studies are Naomi A. Mayman, B.S.; Stanley Tuhrim, M.D.; Nathalie Jette, M.D., M.Sc.; and Mandip S. Dhamoon, M.D., Dr.P.H.

No funding sources or disclosures were reported.

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The American Stroke Association’s International Stroke Conference (ISC) is the world’s premier meeting dedicated to the science and treatment of cerebrovascular disease. ISC 2021 will be held virtually, March 17-19, 2021. The 3-day conference features more than 1,200 compelling presentations in 21 categories that emphasize basic, clinical and translational sciences as they evolve toward a better understanding of stroke pathophysiology with the goal of developing more effective therapies. Engage in the International Stroke Conference on social media via #ISC21.

About the American Stroke Association

The American Stroke Association is devoted to saving people from stroke — the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit

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