The research was presented today as one of the Top 10 studies at the ObesityWeek 2019 international conference in Las Vegas.
Research has shown that weight-loss surgery – also known as metabolic or bariatric surgery – can help people control their diabetes and improve cardiovascular health. In 2016, the world’s leading diabetes organizations recommended in a consensus report that metabolic surgery should be a treatment option for people with type 2 diabetes and obesity. However, few eligible patients undergo the surgery.
To help patients and their physicians better predict the health benefits of usual care versus surgical treatment, Ali Aminian, M.D., a bariatric surgeon at Cleveland Clinic, and his research team developed a risk score calculator that provides personalized evidence-based information, based on a patient’s current health status.
“The calculator can be a useful tool for physicians and patients with type 2 diabetes and obesity. It shows a patient’s risk of heart disease, stroke, heart failure, diabetic kidney disease, and death over the next 10 years with usual care. It also shows how a patient’s risk of those adverse events could change after metabolic surgery,” said Dr. Aminian, who is also lead author of the study.
The calculator — 10-year Individualized Diabetes Complications Risk Scores — was developed in two phases over the course of about two years. In the first phase, an observational study looked at nearly 2,300 patients who underwent metabolic surgery and 11,500 matched patients with similar characteristics who received usual medical care.
The phase 1 results, published in the Journal of the American Medical Association (JAMA) in September, show that weight-loss surgery performed in patients with type 2 diabetes and obesity is associated with 40 percent lower risk of death and major adverse cardiovascular events than usual medical care. Surgical patients also lost more weight, had better diabetes control, and used fewer medications for treatment of their diabetes and cardiovascular disease than those undergoing usual medical care.
In phase 2, the researchers used the same group of patients to identify predictors for different health outcomes. Evidence-based models were built and integrated into a risk calculator to estimate the likelihood of coronary heart disease, stroke, heart failure, diabetic kidney disease, and mortality over the next 10 years in patients with type 2 diabetes and obesity with and without bariatric surgery
“Based on the advice of subject matter experts, our team was able to explore 26 risk factors for the different outcomes, including risk of dying, in that large group of patients,” said Michael Kattan, Ph.D., chairman of the Department of Quantitative Health Sciences in Cleveland Clinic’s Lerner Research Institute. “We then compared machine learning and traditional statistical techniques to identify the most accurate prediction models for each outcome and built those into the calculator.”
Steven Nissen, M.D., Chief Academic Officer of the Heart & Vascular Institute at Cleveland Clinic, added, “Diabetes can be a devastating disease and combined with obesity, patients are at a high risk for cardiovascular complications. Metabolic surgery is an underutilized treatment for these patients. This calculator can help both physicians and patients quantify the risks and benefits of surgery and make the best decision for treatment.”
The calculator will be accessible on the Cleveland Clinic Risk Calculator Library website and as a smartphone application (BariatricCalc). The second version of the app with additional calculators will be released during ObesityWeek 2019.
This study was partially funded by an unrestricted grant from Medtronic. Medtronic had no role in the design, conduct of the study, or reporting of the results.
About Cleveland Clinic
Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual “America’s Best Hospitals” survey. Among Cleveland Clinic’s 66,000 employees are more than 4,200 salaried physicians and researchers and 16,600 nurses, representing 140 medical specialties and subspecialties. Cleveland Clinic’s health system includes a 165-acre main campus near downtown Cleveland, 11 regional hospitals in northeast Ohio, more than 180 northern Ohio outpatient locations – including 18 full-service family health centers and three health and wellness centers – and locations in southeast Florida; Las Vegas, Nev.; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2018, there were 7.9 million total outpatient visits, 238,000 hospital admissions and observations, and 220,000 surgical cases throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 185 countries. Visit us at clevelandclinic.org. Follow us at twitter.com/CCforMedia and twitter.com/ClevelandClinic. News and resources available at newsroom.clevelandclinic.org.
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