New study finds antidepressant drug effective in treating “lazy eye” in adults

In a new study, published in Current Biology, researchers from the University of California, Irvine School of Medicine reveal how subanesthetic ketamine, which is used for pain management and as an antidepressant in humans, is effective in treating adult amblyopia, a brain disorder commonly known as “lazy eye.”

The Novel Role of Microglia as Modulators of Neurons in the Brain Is Discovered by Mount Sinai Researchers

Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease

Scientists Capture Candid Snapshots of Electrons Harvesting Light at the Atomic Scale

A team of scientists led by Berkeley Lab has gained important new insight into electrons’ role in the harvesting of light in artificial photosynthesis systems.

Women and Racial Minorities are Marginalized in Trials of Medications for Alcohol Use Disorder

Women and racial minorities are seriously underrepresented in trials of medicines for alcohol use disorder (AUD) despite evidence that these treatments affect demographic groups differently. This is according to a review in Alcoholism: Clinical & Experimental Research, which may be the first to evaluate sex and racial representation in studies relating to the three pharmacological treatments approved by the Food and Drug Administration (FDA) for AUD. Previous research indicates that sex and race/ethnicity likely influence the prevalence of AUD, its risk of health consequences, and the effectiveness of treatments.

Seekers Versus Non-Seekers of Treatment for Alcohol Dependence: Implications for Drug Development

A new report has highlighted key differences between participants in early and later stages of drug research for alcohol use disorder (AUD), which could affect study findings and confound evaluations of novel treatments. In the US, only 4% of people with diagnosed AUD receive medication to treat their condition, and currently only three drugs are approved for this purpose. Early-stage laboratory studies of new treatments, which often involve controlled alcohol use, usually enroll heavy drinkers who have not sought treatment for their AUD. Later-stage trials, however, typically enroll patients who have sought treatment (and hence better reflect those who might be prescribed an approved treatment in clinical practice). A lower motivation and ‘readiness to change’ of non-treatment seekers compared with treatment seekers could affect drinking behavior and medication adherence in research studies. As such, it is vital to compare these groups and assess for differences that could influence s

Political Polarization: Often Not as Bad as We Think

As politics grows increasingly polarized, a new global study finds people often exaggerate political differences and negative feelings of those on the opposite side of the political divide, and this misperception can be reduced by informing them of the other side’s true feelings. The study replicates earlier research in the United States, finding the phenomenon to be generalizable across 25 countries.

Screen time can change visual perception — and that’s not necessarily bad

The coronavirus pandemic has shifted many of our interactions online, with Zoom video calls
replacing in-person classes, work meetings, conferences and other events. Will all that screen time damage our vision? Maybe not. It turns out that our visual perception is highly adaptable, according to research from Psychology Professor and Cognitive and Brain Sciences Coordinator Peter Gerhardstein’s
lab at Binghamton University.

Study Explores Link Between Methamphetamine Use And Risky Sexual Behavior

Recreational use of the illicit drug methamphetamine has long been associated with increases in overall impatient and risky behavior. Now, a new study by Johns Hopkins Medicine researchers affirms that meth use increases not only sexual desire but also, specifically and measurably, the risk of casual sex without a condom for those who have an increase in sexual desire.

Research into SARS-CoV-2 mutation “hotspots” raises implications for vaccines and therapeutics

Researchers have found at least 10 distinct “hotspot” mutations in more than 80% of randomly selected SAR-CoV-2 sequences from six countries, and these genome hotspots – seen as “typos” that can occur as the virus replicates during cellular division – could have a significant impact in the fight against the COVID-19 pandemic.

Cerebral palsy also has genetic underpinnings

Scientists have identified mutations in single genes that can be responsible for at least some cases of cerebral palsy, according to a new study led by researchers at Washington University School of Medicine in St. Louis. The study indicates that many of the mutations occur randomly and are not inherited from a child’s parents. The new knowledge could help improve the diagnosis of cerebral palsy and lead to future therapies.

Researchers use amino acids to grow high-performance copper thin films

For the first time, researchers from Missouri S&T have shown that highly ordered copper thin films can be crystallized directly on a one-molecule-thick layer of organic material rather than on the inorganic substrates that have been used for years.The copper thin films they’ve produced are excellent candidates for use as underlying substances for solar cells, LEDs, and high-temperature superconductors, says Dr.

World’s First ‘Pathoconnectome’ Could Point Toward New Treatments for Neurodegenerative Diseases

Scientists from the John A. Moran Eye Center at the University of Utah have achieved another first in the field of connectomics, which studies the synaptic connections between neurons. The National Institutes of Health (NIH)-funded lab has produced the first pathoconnectome, showing how eye disease alters retinal circuitry.

Can Mobile Technology Offer New Pathways to Improve Recovery For Patients Who Experience Serious Traumatic Injuries?

Serious traumatic injuries are a health event that can begin a trajectory toward chronic health and social challenges. Research on patient outcomes following traumatic injuries establishes the pervasive nature of injuries’ long-term consequences in physical, psychological, social and economic well-being, which may persist months and even years after an injury hospitalization. In light of this research, emerging interventions have targeted enhanced and coordinated healthcare services to support recovery and address patients’ long-term rehabilitative needs.

Exosome treatment improves recovery from heart attacks in a preclinical study

Research in pigs shows that using the exosomes naturally produced from a mix of heart muscle, endothelial and smooth muscle cells — all derived from human induced pluripotent stem cells — yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells.

Finding Right Drug Balance for Parkinson’s Patients

Parkinson’s disease is most commonly treated with levodopa, but the benefits wear off as the disease progresses and high doses can result in dyskinesia, which are involuntary and uncontrollable movements. To better understand the underlying reasons behind these effects, researchers created a model of the interactions between levodopa, dopamine, and the basal ganglia, an area of the brain that plays a crucial role in Parkinson’s disease. They discuss their findings in the journal Chaos.

Evolution of Pine Needles Helps Trees Cope with Rainfall Impact

If you have been surrounded by the sight and smell of pine trees, you may have taken a closer look at the needles and then wondered how their properties are influenced by rainfall. In Physics of Fluids, researchers are currently probing how well pine needles allay the impact of rain beneath the tree. They explored the impact of raindrops onto fixed, noncircular fibers of the longleaf pine by using high-speed videography to capture the results.

Argonne researchers target lithium-rich materials as key to more sustainable, cost-effective, next-generation batteries

Researchers are developing new ways to advance lithium-rich batteries and using new materials for practical use, according to researchers with the U.S. Department of Energy’s Argonne National Laboratory.