New drug combination shows promise as powerful treatment for AML

Scientists have identified two drugs that are potent against acute myeloid leukemia (AML) when combined, but only weakly effective when used alone. The researchers were able to significantly enhance cancer cell death by jointly administering the drugs that are only partially effective when used as single-agent therapies.

Researchers use lasers and molecular tethers to create perfectly patterned platforms for tissue engineering

University of Washington researchers developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages to affect cell behavior. Their approach uses near-infrared lasers to trigger chemical adhesion of proteins to scaffolds made from biological polymers like collagen.

Scientists Streamline Process for Controlling Spin Dynamics

UPTON, NY—Marking a major achievement in the field of spintronics, researchers at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and Yale University have demonstrated the ability to control spin dynamics in magnetic materials by altering their thickness. The study, published today in Nature Materials, could lead to smaller, more energy-efficient electronic devices.

UCI researchers: Climate change will alter the position of the Earth’s tropical rain belt

Irvine, Calif., Jan. 18, 2021 — Future climate change will cause a regionally uneven shifting of the tropical rain belt – a narrow band of heavy precipitation near the equator – according to researchers at the University of California, Irvine and other institutions. This development may threaten food security for billions of people.

Mount Sinai Researchers Build Models Using Machine Learning Technique to Enhance Predictions of COVID-19 Outcomes

Mount Sinai researchers have published one of the first studies using federated learning to examine electronic health records to better predict how COVID-19 patients will progress.

Rapid blood test identifies COVID-19 patients at high risk of severe disease

Scientists at Washington University School of Medicine in St. Louis have shown that a relatively simple and rapid blood test can predict which patients with COVID-19 are at highest risk of severe complications or death. The blood test measures levels of mitochondrial DNA, which normally resides inside the energy factories of cells. Mitochondrial DNA spilling out of cells and into the bloodstream is a sign that a particular type of violent cell death is taking place in the body.

Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences

in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.

COVID-19 deaths really are different. But best practices for ICU care should still apply, studies suggest.

COVID-19 deaths are indeed different from other lung failure deaths, according to two recent studies, with 56% of COVID-19 patients dying primarily from the lung damage caused by the virus, compared with 22% of those whose lungs fail due to other causes. But, the researchers conclude, the kind of care needed to help sustain people through the worst cases of all forms of lung failure is highly similar, and just needs to be fine-tuned.

45% of adults over 65 lack online medical accounts that could help them sign up for COVID-19 vaccinations

As the vaccination of older adults against COVID-19 begins across the country, new poll data suggests that many of them don’t yet have access to the “patient portal” online systems that could make it much easier for them to schedule a vaccination appointment. In all, 45% of adults aged 65 to 80 had not set up an account with their health provider’s portal system.

Fight CRC To Present Research Findings on The Impact of COVID-19 on the Colorectal Cancer Community at 2021 GI ASCO

Fight Colorectal Cancer presents abstract at Gastrointestinal Cancer Symposium highlighting the need to address the barriers and opportunities for care within the colorectal cancer community during the COVID-19 pandemic

Mount Sinai Finds That Transgender Women Can Safely Stay On Their Hormone Treatments During Gender Affirming Surgery, Without An Increase of Blood Clots

This is the first study to demonstrate that there is no difference in blood clots when transgender women remain on estrogen hormone therapy for gender affirming surgery. Because both estrogen therapy and surgery can increase a person’s risk of blood clots, experts had long suggested that transgender women stop taking estrogen when undergoing gender affirming surgery. However, there was previously no published data on the blood clot risk specific to transgender women undergoing surgery.

CHOP Researchers Find NTRK Fusions More Common than Expected in Pediatric Tumors

In a large study of pediatric cancer patients, researchers from Children’s Hospital of Philadelphia (CHOP) have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors. The researchers found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors.

Accounting for the gaps in ancient food webs

Studying ancient food webs can help scientists reconstruct communities of species, many long extinct, and even use those insights to figure out how modern-day communities might change in the future. There’s just one problem: only some species left enough of a trace for scientists to find eons later, leaving large gaps in the fossil record — and researchers’ ability to piece together the food webs from the past.

A new paper shines a light on those gaps and points the way to how to account for them.

Acute itching in eczema patients linked to environmental allergens

New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn’t respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don’t target.

UNH Researchers Discover New Inhibitor Drug Combination for Rare Form of Cancer

Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that were effective in reducing the growth of the cancer cells and when combined with a third drug were even more successful in killing the WM cancer cells which could lead to more treatment options.