Dr. Will’s award will help fund her studies on the mechanisms that create and sustain cancer stem cells–a unique and therapy-resistant population of cancer cells in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), two age-related and largely incurable blood cancers.
“I’m very excited and honored that the Pershing Square Sohn Cancer Research Alliance selected me for this award,” Dr. Will said. “The prize will boost my lab’s efforts to make scientific advances that can help us better understand these cancers and work toward developing drugs that can benefit patients. With every publication, with every piece of data we put out there, we increase the knowledge and our ability to help patients. Being able to work on this every day is a real privilege.”
When people have AML or MDS, a small population of cancerous blood stem cells, called leukemic stem cells (LSCs), resists chemotherapy and causes the cancers to relapse. Dr. Will plans to investigate how iron influences LSCs. Specifically, she will study iron regulatory pathways, key processes that determine how cells acquire and use this essential nutrient. In research involving mouse models of myeloid leukemia and human LSCs, she will determine whether limiting the cells’ access to iron can slow or prevent cancer growth. Results could lead to new drugs that could limit iron availability and make cancer stem cells more susceptible to chemotherapy.
Dr. Will noted that the prize specifically supports early-stage research that is impossible to get funded through traditional grants. “The Pershing Square Sohn Alliance’s mission stresses that no one should be afraid to start something new and out-of-the-box,” said Dr. Will, whose lab includes four postdoctoral researchers, a Ph.D. student, and several technicians. “This award enables us to step out of our comfort zone. It’s also a great encouragement that provides an ecosystem for younger trainees on these projects to develop their careers.”
“This is a well-deserved honor for Dr. Will,” said Roman Perez-Soler, M.D., chief of medical oncology at Einstein and chair of oncology at Montefiore Health System. “Her creative and bold research earned her this award and we look forward to her continued success and scientific discoveries.”
Dr. Will is the second Einstein faculty member to win the Pershing Square Sohn prize; in 2015, the Alliance awarded the honor to Evripidis Gavathiotis, Ph.D., professor of biochemistry and of medicine.
About Albert Einstein College of Medicine
Albert Einstein College of Medicine is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2019-20 academic year, Einstein is home to 724 M.D. students, 158 Ph.D. students, 106 students in the combined M.D./Ph.D. program, and 265 postdoctoral research fellows. The College of Medicine has more than 1,800 full-time faculty members located on the main campus and at its clinical affiliates. In 2019, Einstein received more than $178 million in awards from the National Institutes of Health (NIH). This includes the funding of major research centers at Einstein in aging, intellectual development disorders, diabetes, cancer, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Einstein runs one of the largest residency and fellowship training programs in the medical and dental professions in the United States through Montefiore and an affiliation network involving hospitals and medical centers in the Bronx, Brooklyn and on Long Island. For more information, please visit www.einstein.yu.edu, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube.
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