False-negative COVID-19 test results may lead to false sense of security

As COVID-19 testing becomes more widely available, it’s vital that health care providers and public health officials understand its limits and the impact false results can have on efforts to curb the pandemic.
A special article published in Mayo Clinic Proceedings calls attention to the risk posed by overreliance on COVID-19 testing to make clinical and public health decisions. The sensitivity of reverse transcriptase–polymerase chain reaction (RT-PCR) testing and overall test performance characteristics have not been reported clearly or consistently in medical literature, the article says.

Mayo Clinic offer guidance on treating COVID-19 patients with signs of acute heart attack

Much remains unknown about COVID-19, but many studies already have indicated that people with cardiovascular disease are at greater risk of COVID-19. There also have been reports of ST-segment elevation (STE), a signal of obstructive coronary artery disease, in patients with COVID-19 who after invasive coronary angiography show no sign of the disease. This false signal of coronary artery disease may cause patients to undergo procedures that present unnecessary risks, especially in the COVID-19 environment, according to a special article published in Mayo Clinic Proceedings.

Researchers Reveal Important Genetic Mechanism Behind Inflammatory Bowel Disease

Researchers at Children’s Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target.

Mount Sinai Researchers Discover a Novel Role for Dopamine That Impacts Gene Expression Related to Cocaine Abuse

Scientists at the Icahn School of Medicine at Mount Sinai have discovered a new role for the brain chemical dopamine that is independent of classic neurotransmission. The new role appears to be critical to changes in gene expression related to chronic exposure to, or abuse of, cocaine, according to a study published Friday, April 10, in the journal Science.

University of Kentucky Researcher Leads First Human Study of Drug Targeting Brain Inflammation

A study examining MW189 in healthy adult volunteers was performed by a collaborative team from the University of Kentucky, Duke University and Northwestern University. The work by Van Eldik and the rest of the team is substantial as it is the first time MW189 had been tested in humans.

Identical Mice, Different Gut Bacteria, Different Levels of Cancer

Some types of gut bacteria are better than others at stimulating certain immune cells, specifically CD8+ T cells. And while these CD8+ T cells normally help protect the body against cancer, overstimulating them may promote inflammation and exhaust the T cells — which can actually increase susceptibility to cancer, according to new mouse model study published in Cell Reports.

Measuring the Risk Among Clinicians Who Intubate Patients with COVID-19

Penn launched the U.S. component of a global registry that aims to help protect health care providers who intubate patients with COVID-19 and quantify their risk of developing the disease. The intubateCOVID registry tracks exposures and outcomes among providers who perform intubations, with the ultimate goal of reducing the transmission of COVID-19 to these providers.

MORE THAN A DOZEN WILLS EYE HOSPITAL FACULTY AND ALUMNI NAMED ON ANNUAL GLOBAL POWER LIST OF TOP 100 MOST INFLUENTUAL OPHTHALMOLOGISTS

The 2020 Power List is out and six Wills Eye Hospital faculty Ophthalmologists are named among the most influential figures in the field based on their scope of knowledge and professional achievements. Director of the Wills Eye Ocular Oncology Service Carol L. Shields, MD was listed the #1 most influential ophthalmologist in the world and the only female physician to make the top 10. Leaders were selected based on nominations from readers of the U.K.-based news magazine, The Ophthalmologist that publishes the list. The final top 100 list was released in March 2020.

Moffitt Researchers Develop Mathematical Model to Predict Patient Outcomes to Adaptive Prostate Cancer Therapy

In an article published in Nature Communications, Moffitt Cancer Center researchers provide a closer look at a mathematical model and data showing that individual patient alterations in the prostate-specific antigen (PSA) biomarker early in cancer treatment can predict outcomes to later treatment cycles of adaptive therapy.

West Virginia University partnerships help WVU Medicine community and beyond amidst personal protective equipment shortage

Josh Bintrim and Kelsey Crawford have worked in collaboration with Innovation Hub Director Gene Cilento, Assistant Director Kolin Brown and health care professionals at WVU Health Sciences Center to design surgical mask extenders, face shields and intubation boxes for use in medical facilities.

FaceTime, Faith and Zoom’ing Through Holy Week; UNH Expert on Worshipping During COVID-19

For most religions, coming together as a community to worship is at the core of their practice, but during this unique and unsettling time of mask wearing and social distancing praying together can be a challenge as many churches remain closed during the coronavirus pandemic. Michele Dillon, a scholar of Catholicism and professor of sociology at the University of New Hampshire, finds that during one of the most holy periods on the Christian calendar clergy and parishioners are learning to make the liturgy work as online events, while continuing to follow COVID-19 guidelines.

UPMC Leads Global Effort to Fast Track Testing of Hydroxychloroquine and other COVID-19 Therapies with ‘Learning While Doing’ Clinical Trial

Novel ‘learning while doing’ clinical trial approach called REMAP helps doctors find the optimal trade-off between quickly adopting new therapies during a pandemic, such as the anti-malarial drug hydroxychloroquine, and waiting until they are tested in longer clinical trials. The trial announced today at UPMC, called UPMC-REMAP-COVID19 learns from similar trials enrolling around the world and uses artificial intelligence to quickly arrive at answers.

Clinical trial launches to evaluate antimalarial drugs for COVID-19 treatment

Washington University School of Medicine in St. Louis is launching a clinical trial for patients hospitalized with COVID-19 at Barnes-Jewish Hospital. The trial will investigate the effectiveness of different combinations of the antimalarial drugs chloroquine and hydroxychloroquine and the antibiotic azithromycin in treating ill patients infected with the novel coronavirus.

Mount Sinai Study Finds First Cases of COVID-19 in New York City are Primarily from European and US Sources

First definitive molecular epidemiology study of SARS-CoV-2 in New York City to describe the route by which the virus arrived

University of Utah Health and Intermountain Healthcare Launch Two COVID-19 Clinical Trials to Test Effectiveness of Drugs

Researchers from Intermountain Healthcare and University of Utah Health in Salt Lake City have launched two vital clinical trials to test the effectiveness and safety of two drugs –hydroxychloroquine (HCQ) and azithromycin – to treat patients with COVID-19 (infection with the novel coronavirus).

JNCCN: Improving COVID-19 Safety for Cancer Patients and Healthcare Providers

NCCN Best Practices Committee publishes peer-reviewed feature in JNCCN presenting latest insights on how to keep oncology patients and healthcare workers safe during COVID-19 pandemic. Visit NCCN.org/covid-19 for continually-updated resources for patients, providers, and care systems.

Hungry for a Fresh Start to Stay Healthy and Calm in Anxious Times? Experts Share Insights in Webinar Series

Members of the restaurant and foodservice community are among the groups that are most affected by the COVID-19 pandemic. In these anxious times, it’s more important than ever to take care of our physical and emotional health. Dr/Chef Rob Graham, Co-Founder and Chief Medical Officer of FRESH Medicine and Peggy Neu, President of The Monday Campaigns, will share advice for staying healthy and managing stress during these challenging times.

University of Redlands Professor Marcia McFee says though we can’t gather, we can still celebrate Easter, Passover, or Ramadan. “In fact, it is perhaps essential to do so, in this moment, this year.”

University of Redlands Professor Marcia McFee says though we can’t gather, we can still celebrate Easter, Passover, or Ramadan. “In fact, it is perhaps essential to do so, in this moment, this year.” “In the Easter story, human pathos meets…

Science Snapshots from Berkeley Lab: 3D nanoparticles and magnetic spin

Researchers at Berkeley Lab have captured 3D images of nanoparticles in liquid with atomic precision, and developed an ultrathin electrical switch that could further miniaturize computing devices and personal electronics without loss of performance.